Descripció del projecte
TET2 is an epigenetic enzyme that acts as tumor suppresor and is known for its role as a regulator of tumor cell fate. Modulation of the activity of this enzyme in different molecular scenarios gives rise to the apoptosis and elimination of these cells. Developing first-in-class pharmacological modulators of tet2 that regulate its activity beyond a therapeutic threshold constitutes a novel approach to eliminate tumor cells, even those persistent tumor cells that are refractory to current treatments. The project of this thesis will encompass the study of the efficacy of pharmacological modulators of TET2 in different cancer indications and the elucidation of the molecular mechanism of action implicated in its antitumoral effects, aiming to translate these results into the clinic. This work will be codirected from UB, Oniria and VHIO.
