Descripció del projecte
Drug manufacturers need new biocompatible materials with improved mechanical properties and increased drug stability. New drugs and compounds are being synthesized that require inert materials to prevent any contamination from the tubing to the drug being produced. In order to develop new materials to fulfill this need this project proposes three subaims:
1. Study the effect of novel additives in the mechanical properties of the tubing. Individual additives as well as combination of the additives at different percentages will be added to the raw material. These materials will exposed to different manufacturing conditions and aging processes and different mechanical properties such microhardness, impact resistance, yield strength, ultimate strength and elastic moduli at different temperature conditions using industry standards.
2. The optimal combination of additives will be further studied in several extraction tests using USP665 procedures. The goal of this subaim is to determine the profile of extracted substances from these materials under production conditions. The materials developed in this study need to be inert and stable in different drug manufacturing conditions. To this end, we will use different solvent to perform extractions according to the norm USP665 and identify the extracted components using chromatography techniques.
3. The last subaim will be done in collaboration with external laboratories to assess the biocompatibility of the novel materials developed by testing its effect on cell growth, protein expression, drug stability, biofilm formation and protein binding.
Fulfillment of this work will provide the pharmaceutical and biotechnological industry with improved manufacturing materials to ensure optimal conditions for the manufacturing of the next life-saving drug or technology.
